Description

Ad80 CAS NO 1384071-99-1 is a potent and selective small molecule inhibitor of the serine/threonine kinase Akt (Protein Kinase B). This compound is crucial for researchers and developers in the life sciences sector, as it provides a powerful tool for modulating the PI3K/Akt/mTOR signaling pathway, a central regulator of cell growth, proliferation, and survival. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on oncology, metabolic disorders, and neurodegenerative disease research.

Application

• Biomedical Research: A key reagent for studying the role of Akt signaling in cancer cell proliferation, apoptosis, and chemoresistance.
• Drug Discovery & Development: Used as a reference compound and pharmacological tool in high-throughput screening and target validation for novel oncology therapeutics.
• Signal Transduction Studies: Essential for elucidating downstream effects of PI3K/Akt pathway inhibition in various cellular and animal disease models.
• Academic Research: Employed in university and institutional labs to investigate fundamental biological processes related to cell growth and metabolism.
• Preclinical Studies: Supports in vitro and in vivo efficacy testing for potential therapeutic agents targeting Akt-dependent pathways.

Basic Information

Product Name	Ad80
CAS No.	1384071-99-1
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	Ad80; Akt Inhibitor Ad80; 8-(1-Hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methylamino]-6-phenylimidazo[1,2-a]pyrazine; 6-Phenyl-8-(1-hydroxyethyl)-2-methoxy-3-[(4-methoxyphenyl)methylamino]imidazo[1,2-a]pyrazine; Akt1/2/3 Inhibitor; Protein Kinase B Inhibitor Ad80
EINECS	Contact for details

Quality Control

Our Ad80 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation and NMR for structural verification, to ensure it meets the high standards required for research use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee reproducibility and reliability in your experiments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Allow the vial to warm to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, Ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.