Description

E3 Ligase Ligand-Linker Conjugates 24 (Tfa) is a specialized bifunctional chemical compound designed for the development of Proteolysis-Targeting Chimeras (PROTACs) and other targeted protein degradation technologies. This molecule integrates a ligand for an E3 ubiquitin ligase with a linker, serving as a critical modular component for constructing novel therapeutic agents. It is essential for researchers and developers in pharmaceutical R&D and biotechnology focused on advancing next-generation drug discovery platforms. The compound is supplied as a high-purity building block to ensure reliable and reproducible results in complex synthetic pathways.

Application

• Core Building Block for PROTAC Synthesis: Serves as a key intermediate for constructing heterobifunctional degraders that recruit specific E3 ligases to target proteins of interest.
• Chemical Biology Research: Used in studies exploring ubiquitin-proteasome system (UPS) pathways and validating novel E3 ligases for degradation.
• Preclinical Drug Discovery: Enables the rapid prototyping and optimization of targeted protein degrader candidates for various disease targets.
• Bioconjugation and Linker Chemistry Development: Provides a model compound for studying linker stability, pharmacokinetics, and spacer group effects in bifunctional molecules.
• High-Throughput Screening (HTS) Libraries: Incorporated into diverse compound libraries to identify initial hits for degradation-based therapeutic programs.

Basic Information

Item	Details
Product Name	E3 Ligase Ligand-Linker Conjugates 24 (Tfa)
CAS No.	1957235-75-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	E3 Ligand-Linker Conjugate 24 TFA; PROTAC Linker Conjugate 24 (Tfa); Trifluoroacetic acid salt of E3 Ligase Ligand-Linker 24; VHL Ligand-Linker Conjugate TFA; (2S,4R)-1-((S)-2-(2-(2-(2-(2-(2-(2-(Tert-butoxy)-2-oxoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide TFA salt; E3 Ligase Recruiting Moiety-Linker 24; Targeted Degradation Building Block 24.
EINECS	Contact for details

Quality Control

Our E3 Ligase Ligand-Linker Conjugates 24 (Tfa) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity assessment and MS & NMR for structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other relevant specifications to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive) and light-sensitive; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular ion
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.