Description

Protac Ar Degrader-4 is a potent and selective small molecule degrader designed for targeted protein degradation research. This compound is a critical tool for investigating novel therapeutic strategies in oncology and other disease areas by inducing the degradation of specific proteins of interest. It is primarily utilized by pharmaceutical R&D teams, academic research laboratories, and biotechnology companies focused on pioneering PROTAC (Proteolysis Targeting Chimera) technology and drug discovery.

Application

• PROTAC Technology Development: Serves as a key chemical probe for designing and validating new PROTAC molecules.
• Target Validation Studies: Used to study the biological consequences of degrading specific target proteins in cellular models.
• Mechanism of Action Research: Facilitates the investigation of ubiquitin-proteasome system (UPS) engagement and degradation kinetics.
• Oncology Research: Applied in preclinical studies to evaluate the therapeutic potential of targeted protein degradation in cancer cell lines and animal models.
• Chemical Biology Tool: Employed to explore novel signaling pathways and identify synthetic lethal interactions.
• High-Throughput Screening (HTS): Can be used as a reference compound in screening assays for discovering new E3 ligase binders or linker optimizations.

Basic Information

Product Name	Protac Ar Degrader-4
CAS No.	1351169-31-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC AR Degrader-4; ARCC-4; AR Degrader-4; AR-targeting PROTAC; Androgen Receptor Degrader-4; Proteolysis Targeting Chimera for Androgen Receptor; (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-4-Methyl-1-[[(2S,3R)-1-oxo-3-phenyl-1-[[(1S,2R,4R)-7-oxabicyclo[2.2.1]heptan-2-yl]amino]butan-2-yl]amino]-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]-2-[[4-[[4-(cyclopentylamino)-6-[(3,5-dimethyl-1H-pyrazol-4-yl)amino]pyrimidin-2-yl]amino]phenyl]formamido]pentanediamide
EINECS	Contact for details

Quality Control

Our Protac Ar Degrader-4 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency for research applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via mass spectrometry. Certificates of Analysis (COA) with detailed chromatographic data are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.