Description

Apcin-A is a potent and selective small molecule inhibitor of the anaphase-promoting complex/cyclosome (APC/C), a key regulator of the cell cycle. This compound is a critical research tool for studying cell division, mitotic exit, and protein degradation pathways in both basic and applied biomedical research. It is essential for scientists and R&D teams in the pharmaceutical, biotechnology, and academic sectors who are investigating novel cancer therapeutics, cell cycle mechanisms, and targeted protein degradation strategies.

Application

• Biomedical Research: Fundamental studies on cell cycle regulation, mitosis, and the role of the APC/C complex.
• Oncology Research: Investigation of novel cancer treatment pathways by targeting cell cycle checkpoints and protein stability.
• Drug Discovery & Development: Used as a pharmacological probe in high-throughput screening and target validation for anticancer agents.
• Biochemical Assays: A key reagent in in vitro and cellular assays to inhibit APC/C activity and study substrate degradation.
• Academic Research: A standard tool in molecular biology and cell biology laboratories for graduate and postdoctoral research projects.
• Pharmaceutical R&D: Supporting the development of targeted protein degradation (TPD) platforms and next-generation therapeutic modalities.

Basic Information

Product Name	Apcin-A
CAS No.	1683617-62-0
Molecular Formula	C₁₉H₂₀N₄O₂
Molecular Weight	336.39 g/mol
Synonyms	APC Inhibitor; Apcin; (R)-Apcin; (R)-N-((1-(4-Chlorophenyl)cyclopropyl)methyl)-1-methyl-1H-pyrazole-4-carboxamide; APC/C Inhibitor Apcin-A; C19H20ClN4O2; TCMDC-135051; Probe APC inhibitor; Apcin A
EINECS	Contact for details

Quality Control

Our Apcin-A is produced under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, potency, and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications. We adhere to industry best practices to support your research with reliable and well-characterized biochemical tools.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.