Description

3-[(tert-Butyldimethylsilyl)Oxy]-2-Chloro-6-Fluorophenylboronic Acid is a sophisticated, multi-functional organoboron building block designed for advanced synthetic chemistry. This compound matters for its role as a key intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily needed by pharmaceutical and agrochemical R&D teams for the synthesis of active ingredients, as well as by academic and industrial researchers in material science.

Application

• Pharmaceutical Intermediate: A critical building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides and fungicides, leveraging the boronic acid functionality for creating diverse aryl-aryl bonds.
• Material Science Research: Serves as a precursor for creating functionalized polymers and organic electronic materials through controlled polymerization or derivatization.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.
• Ligand and Catalyst Development: Acts as a starting material for synthesizing novel ligands and organometallic catalysts used in asymmetric synthesis.
• Custom Synthesis and Contract Manufacturing: A valuable reagent for CROs and CDMOs offering bespoke chemical synthesis services to the life sciences industry.

Basic Information

Product Name	3-[(tert-Butyldimethylsilyl)Oxy]-2-Chloro-6-Fluorophenylboronic Acid
CAS No.	2377611-81-7
Molecular Formula	C₁₂H₁₉BClFO₂Si
Molecular Weight	288.62 g/mol
Synonyms	(2-Chloro-6-fluoro-3-((tert-butyldimethylsilyl)oxy)phenyl)boronic acid; 2-Chloro-6-fluoro-3-[(tert-butyldimethylsilyl)oxy]benzeneboronic acid; 3-(tert-Butyldimethylsiloxy)-2-chloro-6-fluorophenylboronic acid; 2-Chloro-6-fluoro-3-(TBDMS-oxy)phenylboronic acid; TBDMS-protected chloro-fluorophenylboronic acid; (3-(Tert-butyldimethylsilyloxy)-2-chloro-6-fluorophenyl)boronic acid; Boronic acid, B-[2-chloro-6-fluoro-3-[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl]-
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for high-purity research chemicals. Every batch is characterized using advanced analytical techniques including NMR, HPLC, and mass spectrometry to confirm identity and purity. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and supporting your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.