Description

5-Fluoro-4-Methyl-2-Nitrophenylboronic Acid, Pinacol Ester is a high-purity, synthetically valuable organoboron building block, specifically a protected boronic acid derivative. This compound is essential for facilitating efficient and selective cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are fundamental to modern pharmaceutical and advanced materials research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures. The pinacol ester group enhances stability, making it a reliable reagent for demanding synthetic sequences.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates containing complex biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated and nitrated aromatic structures.
• Material Science Research: Employed in the creation of organic electronic materials, such as those for OLEDs or organic photovoltaics, where precise molecular engineering is critical.
• Cross-Coupling Reactions: Serves as a crucial coupling partner in palladium-catalyzed Suzuki-Miyaura reactions to form carbon-carbon bonds with high fidelity.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and tags for studying biological systems and diagnostic applications.
• Academic & Contract Research: A valuable reagent for methodological development and complex natural product synthesis in academic and industrial research laboratories.

Basic Information

Product Name	5-Fluoro-4-Methyl-2-Nitrophenylboronic Acid, Pinacol Ester
CAS No.	2377611-45-3
Molecular Formula	C₁₃H₁₇BFNO₄
Molecular Weight	281.09 g/mol
Synonyms	5-Fluoro-4-methyl-2-nitrophenylboronic acid pinacol ester; 2-Nitro-5-fluoro-4-methylbenzeneboronic acid pinacol ester; (5-Fluoro-4-methyl-2-nitrophenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-(5-fluoro-4-methyl-2-nitrophenyl)-1,3,2-dioxaborolane; Pinacol (5-Fluoro-4-methyl-2-nitrophenyl)boronate; Boronic acid, B-(5-fluoro-4-methyl-2-nitrophenyl)-, 1,1-dimethylethyl ester (9CI)
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoro-4-Methyl-2-Nitrophenylboronic Acid, Pinacol Ester undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive synthetic applications. Our quality assurance protocols include identity confirmation, purity assessment, and impurity profiling using advanced techniques like HPLC, NMR, and LC-MS. Certificates of Analysis (COA) detailing all specifications and test results are provided with each shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.