Description

4-Fluoro-3-Piperidinomethylphenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a crucial building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a piperidine moiety that can serve as a key pharmacophore or handle for further derivatization. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the efficient synthesis of novel, complex molecules, particularly in drug discovery programs targeting central nervous system (CNS) and other therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates containing fluorinated aryl and heterocyclic amine motifs.
• Suzuki-Miyaura Cross-Coupling: The pinacol-protected boronic ester group enables efficient, palladium-catalyzed carbon-carbon bond formation with aryl/heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Drug Discovery & Medicinal Chemistry: Used to rapidly generate diverse compound libraries for high-throughput screening (HTS) and structure-activity relationship (SAR) studies.
• Agrochemical Research: Serves as a building block for developing novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science: Potential monomer or cross-linker in the synthesis of advanced polymers and functional organic materials.
• Ligand Synthesis: The piperidine nitrogen can be utilized to create novel ligands for catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Fluoro-3-Piperidinomethylphenylboronic Acid Pinacol Ester
CAS No.	2377611-14-6
Molecular Formula	C18H27BFNO2
Molecular Weight	319.23 g/mol
Synonyms	4-Fluoro-3-(piperidin-1-ylmethyl)phenylboronic acid pinacol ester; 2-(4-Fluoro-3-(piperidin-1-ylmethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(Piperidin-1-ylmethyl)-4-fluorobenzeneboronic acid pinacol ester; 4-Fluoro-3-(1-piperidinylmethyl)benzeneboronic acid pinacol ester; PINACOL 4-FLUORO-3-(PIPERIDIN-1-YLMETHYL)BENZENEBORONATE; 2377611-14-6; BRN 2377611-14-6
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Piperidinomethylphenylboronic Acid Pinacol Ester is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP principles where applicable, ensuring consistent quality and traceability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its hygroscopic and moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.