Description

5-(T-Butyldimethylsilyloxy)-2-Fluorophenylboronic Acid Pinacol Ester is a high-purity, advanced boronic ester building block designed for complex organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, particularly in the construction of challenging molecular architectures. It is an essential intermediate for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries.

Application

• Pharmaceutical Intermediate: Key building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel active pharmaceutical ingredients (APIs), especially fluorinated compounds.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides that require fluorinated aromatic structures.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic electronic materials for displays and lighting.
• Polymer Chemistry: Enables the incorporation of functionalized aromatic units into specialty polymers and dendrimers.
• Chemical Biology Probes: Utilized in the creation of tagged molecules and bioconjugates for diagnostic and research applications.
• Catalyst Ligand Development: Acts as a starting material for synthesizing novel ligands used in asymmetric catalysis.

Basic Information

Product Name	5-(T-Butyldimethylsilyloxy)-2-Fluorophenylboronic Acid Pinacol Ester
CAS No.	2377611-08-8
Molecular Formula	C₁₈H₃₀BFO₃Si
Molecular Weight	352.33 g/mol
Synonyms	5-[(tert-Butyldimethylsilyl)oxy]-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-5-[(tert-butyldimethylsilyl)oxy]benzeneboronic acid pinacol ester; 5-(tert-Butyldimethylsiloxy)-2-fluorophenylboronic acid pinacol ester; 2-Fluoro-5-(TBDMS-oxy)phenylboronic acid pinacol ester; 5-(TBDMSO)-2-Fluorophenyl-Bpin; (5-((tert-Butyldimethylsilyl)oxy)-2-fluorophenyl)boronic acid pinacol ester; 2377611-08-8; TBDMS-protected fluorophenyl boronate
EINECS	Contact for details

Quality Control

Our 5-(T-Butyldimethylsilyloxy)-2-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment. We adhere to cGMP standards where applicable to support our customers in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.