Description

3-Fluoro-4-(Piperidinomethyl)Phenylboronic Acid Pinacol Ester is a sophisticated boronic ester derivative, a critical building block in modern synthetic chemistry. Its value lies in its dual functionality, combining a protected boronic acid group for Suzuki-Miyaura cross-coupling reactions with a piperidinomethyl moiety that offers a handle for further functionalization and solubility modulation. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries engaged in the development of novel small molecule therapeutics and advanced materials. The CAS number for this compound is 2377608-45-0.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and inflammation.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile coupling partner for the formation of carbon-carbon bonds, enabling the construction of complex biaryl and heterobiaryl scaffolds common in drug discovery.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific fluorine-substituted aromatic systems.
• Material Science: Employed in the synthesis of organic electronic materials, such as those used in OLEDs and organic photovoltaics, where the boronic ester group facilitates polymerization or conjugation extension.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Acts as a linker or functional component in the design of bifunctional molecules for targeted protein degradation.
• Ligand & Catalyst Development: The piperidine nitrogen can be utilized to create novel ligands for asymmetric catalysis or metal-organic frameworks (MOFs).

Basic Information

Product Name	3-Fluoro-4-(Piperidinomethyl)Phenylboronic Acid Pinacol Ester
CAS No.	2377608-45-0
Molecular Formula	C18H27BFNO2
Molecular Weight	319.23 g/mol
Synonyms	[4-(Piperidin-1-ylmethyl)-3-fluorophenyl]boronic acid pinacol ester; 3-Fluoro-4-(piperidin-1-ylmethyl)benzeneboronic acid pinacol ester; (3-Fluoro-4-((piperidin-1-yl)methyl)phenyl)boronic acid pinacol ester; Pinacol 3-Fluoro-4-(piperidinomethyl)benzeneboronate; B-[3-Fluoro-4-(1-piperidinylmethyl)phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2377608-45-0; Boronic acid, B-[3-fluoro-4-[(1-piperidinyl)methyl]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our 3-Fluoro-4-(Piperidinomethyl)Phenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.