Description

3-(T-Butyldimethylsilyloxy)-4-Fluorophenylboronic Acid is a sophisticated, multi-functional organoboron building block designed for advanced synthetic chemistry. Its value lies in the synergistic protection of the phenolic hydroxyl group by the TBDMS moiety and the strategic fluorination, enabling precise, sequential cross-coupling reactions under mild conditions. This compound is essential for researchers and process chemists in pharmaceutical development and agrochemical synthesis who require high-purity intermediates to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Suzuki-Miyaura Cross-Coupling: Serves as a critical boronic acid reagent for constructing biaryl and heterobiaryl scaffolds, a fundamental reaction in medicinal chemistry.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorophenyl group enhances biological activity and environmental stability.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where controlled fluorination modulates electronic properties.
• Chemical Biology Probes: Facilitates the synthesis of fluorinated probes and tags for studying biological processes and protein interactions.
• Scale-up Process Development: Supplied to support process chemistry teams in optimizing and scaling routes from laboratory to pilot plant and commercial production.

Basic Information

Product Name	3-(T-Butyldimethylsilyloxy)-4-Fluorophenylboronic Acid
CAS No.	2377608-43-8
Molecular Formula	C₁₂H₂₀BFO₃Si
Molecular Weight	270.18 g/mol
Synonyms	4-Fluoro-3-[(tert-butyldimethylsilyl)oxy]benzeneboronic Acid; 3-[(tert-Butyldimethylsilyl)oxy]-4-fluorobenzeneboronic Acid; 4-Fluoro-3-(TBDMS-oxy)phenylboronic Acid; (4-Fluoro-3-((tert-butyldimethylsilyl)oxy)phenyl)boronic Acid; 3-(tert-Butyl(dimethyl)silyl)oxy-4-fluorophenylboronic Acid; TBDMS-protected 4-Fluoro-3-hydroxyphenylboronic Acid; 3-(TBDMSO)-4-Fluorophenylboronic Acid
EINECS	Contact for details

Quality Control

Our production of 3-(T-Butyldimethylsilyloxy)-4-Fluorophenylboronic Acid adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for critical R&D and scale-up applications. Each lot undergoes comprehensive analytical characterization, including HPLC purity and NMR confirmation. We provide detailed Certificates of Analysis (COA) upon request, documenting all relevant specifications to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect purity and reactivity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.