Description

{4-[(tert-Butyldimethylsilyl)Oxy]-2-Fluorophenyl}Boronic Acid is a sophisticated, multi-functional organoboron building block designed for advanced synthetic chemistry. This compound matters for its role as a key intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily needed by researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries for developing new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical building block in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and oncology research.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection agents, leveraging the fluorinated aromatic moiety for enhanced biological activity and stability.
• Materials Science Research: Serves as a precursor for developing organic electronic materials, such as OLEDs and semiconductors, where the boronic acid group facilitates polymerization or functionalization.
• Chemical Biology Probes: Employed in the synthesis of tagged molecules and probes for studying biological pathways and protein interactions.
• Process Chemistry & Scale-up: Utilized in route development and optimization for the commercial-scale production of fine chemicals and APIs.
• Academic & R&D Laboratories: A valuable reagent for methodological development in organic synthesis and catalysis studies.

Basic Information

Product Name	{4-[(tert-Butyldimethylsilyl)Oxy]-2-Fluorophenyl}Boronic Acid
CAS No.	2377608-27-8
Molecular Formula	C₁₂H₂₀BFO₃Si
Molecular Weight	270.18 g/mol
Synonyms	(4-((tert-Butyldimethylsilyl)oxy)-2-fluorophenyl)boronic acid; 2-Fluoro-4-[(tert-butyldimethylsilyl)oxy]benzeneboronic acid; 4-(tert-Butyldimethylsiloxy)-2-fluorobenzeneboronic acid; B-[4-[(1,1-Dimethylethyl)dimethylsilyl]oxy]-2-fluorophenyl]boronic acid; TBDMS-protected 2-fluoro-4-hydroxybenzeneboronic acid; 2-Fluoro-4-(TBDMSO)phenylboronic acid; CAS 2377608-27-8
EINECS	Contact for details

Quality Control

Our {4-[(tert-Butyldimethylsilyl)Oxy]-2-Fluorophenyl}Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports applications requiring high-purity intermediates for GMP and research-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.