Description

2-Carboxy-4-Fluorophenylboronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a crucial protected intermediate in modern organic synthesis, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the construction of complex biaryl structures. It is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key protected building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates via palladium-catalyzed cross-coupling.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that incorporate fluorinated biphenyl motifs.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and organoboron catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as fluorinated polymers and small molecules for OLEDs or OFETs.
• Chemical Biology Probes: Utilized in the design and synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Custom Synthesis and Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences industry.

Basic Information

Product Name	2-Carboxy-4-Fluorophenylboronic Acid Pinacol Ester
CAS No.	2377607-51-5
Molecular Formula	C₁₄H₁₈BFO₄
Molecular Weight	280.10 g/mol
Synonyms	4-Fluoro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid; (4-Fluoro-2-carboxyphenyl)boronic Acid Pinacol Ester; 2-Fluoro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid; Pinacol (2-Carboxy-4-fluorophenyl)boronate; B-(4-Fluoro-2-carboxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; CAS 2377607-51-5; 2-Fluoro-6-(pinacolatoboryl)benzoic Acid
EINECS	Contact for details

Quality Control

Our 2-Carboxy-4-Fluorophenylboronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) with full batch-specific data are provided to guarantee consistency and traceability for your critical research and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.