Description

4-Chloro-3-Fluoro-2-Methylphenylboronic Acid is a high-purity, synthetically valuable boronic acid derivative, serving as a critical building block in modern organic synthesis. Its core value lies in enabling the precise construction of complex molecular architectures through reliable cross-coupling reactions. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries, where it is used to develop new active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging its halogenated methylphenyl structure for enhanced bioactivity.
• Ligand & Catalyst Development: Serves as a starting material for creating specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as those for OLEDs and semiconductors, where its molecular structure can tune electronic properties.
• Chemical Biology Probes: Utilized to create boronic acid-based probes and sensors for detecting biological analytes or studying enzyme activity.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-fidelity boronic acid reagents.

Basic Information

Product Name	4-Chloro-3-Fluoro-2-Methylphenylboronic Acid
CAS No.	2377606-88-5
Molecular Formula	C7H7BClFO2
Molecular Weight	187.39 g/mol
Synonyms	(4-Chloro-3-fluoro-2-methylphenyl)boronic acid; 2-Methyl-4-chloro-3-fluorophenylboronic acid; 4-Chloro-3-fluoro-o-tolylboronic acid; B-(4-Chloro-3-fluoro-2-methylphenyl)boronic acid; 2377606-88-5; 4-Chloro-3-fluoro-2-methylbenzeneboronic acid
EINECS	Contact for details

Quality Control

Our 4-Chloro-3-Fluoro-2-Methylphenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high chemical purity and identity. Certificates of Analysis (COA) documenting all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.