Description

3-Fluoro-2-Piperidinopyridine-4-Boronic Acid is a high-value, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling the precise construction of complex molecular architectures through reliable cross-coupling reactions. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, especially in kinase inhibitor and central nervous system (CNS) therapeutic research.
• Agrochemical Development: Used to construct complex heterocyclic scaffolds for new-generation herbicides, fungicides, and insecticides with improved efficacy.
• Material Science Research: Employed in the synthesis of organic electronic materials, ligands for catalysis, and functional polymers requiring specific fluorine-substituted motifs.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of chemical probes and activity-based protein profiling (ABPP) reagents.
• Library Synthesis for High-Throughput Screening: Facilitates the rapid generation of diverse compound libraries for hit identification and lead optimization campaigns.
• Catalyst & Ligand Design: Serves as a building block for creating novel bidentate or tridentate ligands used in transition metal catalysis.

Basic Information

Product Name	3-Fluoro-2-Piperidinopyridine-4-Boronic Acid
CAS No.	2377606-55-6
Molecular Formula	C10H14BFN2O2
Molecular Weight	224.04 g/mol
Synonyms	4-Borono-3-fluoro-2-piperidinopyridine; 2-Piperidino-3-fluoropyridine-4-boronic acid; (3-Fluoro-2-(piperidin-1-yl)pyridin-4-yl)boronic acid; 3-Fluoro-2-(1-piperidinyl)-4-pyridineboronic acid; 3-Fluoro-2-piperidin-1-ylpyridine-4-boronic acid; 2377606-55-6; 3-Fluoro-2-piperidino-4-pyridineboronic acid
EINECS	Contact for details

Quality Control

Our 3-Fluoro-2-Piperidinopyridine-4-Boronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for long-term stability. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Typical 97-99%)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.