Description

5-Chloro-4-Fluoro-2-Nitrophenylboronic Acid is a high-value, multi-functional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its unique structure, featuring halogen and nitro substituents, makes it an indispensable reagent for constructing complex molecules via cross-coupling reactions. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS research.
• Agrochemical Synthesis: Used to create advanced herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Employed in the development of organic electronic materials, such as OLEDs and semiconductors, due to its electron-withdrawing nitro group.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis.
• Chemical Biology Probes: Utilized in the creation of boronic acid-based sensors and probes for detecting biological analytes.
• Custom Synthesis and Contract Manufacturing: A vital component for CROs and CDMOs offering bespoke chemical synthesis services.

Basic Information

Product Name	5-Chloro-4-Fluoro-2-Nitrophenylboronic Acid
CAS No.	2377605-87-1
Molecular Formula	C6H4BClFNO4
Molecular Weight	219.36 g/mol
Synonyms	(5-Chloro-4-fluoro-2-nitrophenyl)boronic acid; 2-Nitro-5-chloro-4-fluorobenzeneboronic acid; 5-Chloro-4-fluoro-2-nitrobenzeneboronic acid; Boronic acid, B-(5-chloro-4-fluoro-2-nitrophenyl)-; CAS 2377605-87-1
EINECS	Contact for details

Quality Control

Our 5-Chloro-4-Fluoro-2-Nitrophenylboronic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the exacting standards required for research and development. Certificates of Analysis (COA) with full traceability are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect purity and reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.