Description

5-Carboxy-2,3-Difluorophenylboronic Acid is a high-purity, multifunctional boronic acid derivative that serves as a critical building block in modern synthetic chemistry. Its value lies in the unique combination of a reactive boronic acid group and a carboxylic acid moiety on a difluorinated aromatic ring, enabling precise cross-coupling reactions and further functionalization. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and advanced materials through Suzuki-Miyaura coupling.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the difluorophenyl group imparts specific biological activity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of advanced polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The boronic acid functionality makes it an ideal partner for palladium-catalyzed cross-coupling reactions to form biaryl and heterobiaryl structures.
• Chemical Biology & Proteomics: Can be utilized in the development of chemical probes, inhibitors, or as a handle for bioconjugation due to its orthogonal reactive groups.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	5-Carboxy-2,3-Difluorophenylboronic Acid
CAS No.	2377605-76-8
Molecular Formula	C7H5BF2O4
Molecular Weight	201.93 g/mol
Synonyms	2,3-Difluoro-5-carboxyphenylboronic Acid; (5-Carboxy-2,3-difluorophenyl)boronic Acid; 5-Borono-2,3-difluorobenzoic Acid; 2,3-Difluorobenzoic Acid-5-boronic Acid; B-(5-Carboxy-2,3-difluorophenyl)boronic Acid
EINECS	Contact for details

Quality Control

Every batch of 5-Carboxy-2,3-Difluorophenylboronic Acid is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemicals and pharmaceutical intermediates. Comprehensive analytical testing, including HPLC, NMR, and MS, is performed to verify identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, and custom purity grades are available to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Standard Grade)
Purity (HPLC)	≥99.0% (High Purity Grade)
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.