Description

3,6-Dichloro-2-Fluorophenylboronic Acid is a high-purity organoboron building block essential for modern synthetic chemistry. This compound serves as a critical intermediate in cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily utilized by research institutions and industrial R&D departments in the pharmaceutical and agrochemical sectors for developing new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key reagent in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in medicinal chemistry programs targeting complex heterocycles.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, where the introduction of the fluorophenyl moiety can enhance biological activity and stability.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials through palladium-catalyzed coupling.
• Chemical Biology & Proteomics: Employed in the synthesis of molecular probes and bioconjugates for studying biological processes and protein interactions.
• Catalyst Ligand Development: Acts as a starting material for synthesizing specialized ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and scaled-up processes.

Basic Information

Product Name	3,6-Dichloro-2-Fluorophenylboronic Acid
CAS No.	2377605-67-7
Molecular Formula	C6H4BCl2FO2
Molecular Weight	208.82 g/mol
Synonyms	(3,6-Dichloro-2-fluorophenyl)boronic acid; 2-Fluoro-3,6-dichlorophenylboronic acid; Boronic acid, B-(3,6-dichloro-2-fluorophenyl)-; 3,6-Dichloro-2-fluorobenzeneboronic acid; CAS 2377605-67-7
EINECS	Contact for details

Quality Control

Every batch of 3,6-Dichloro-2-Fluorophenylboronic Acid is manufactured under strict quality management protocols. We guarantee high chemical purity and lot-to-lot consistency, which is critical for reproducible results in sensitive cross-coupling reactions. Comprehensive analytical testing, including HPLC, NMR, and elemental analysis, is performed to verify identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment to ensure full traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.