Description

4-Fluoro-3-[(3-Fluorophenyl)(Hydroxy)Methyl]Phenylboronic Acid is a sophisticated bifunctional boronic acid derivative, serving as a critical building block in modern synthetic chemistry. Its molecular architecture, featuring both a boronic acid group and a fluorinated benzhydrol moiety, makes it an exceptionally versatile intermediate for constructing complex molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors, particularly for the development of new active ingredients through cross-coupling reactions and other advanced synthetic methodologies.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura and other palladium-catalyzed cross-coupling reactions for synthesizing novel drug candidates, especially fluorinated bioactive molecules.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental stability.
• Material Science Research: Employed in the development of organic electronic materials, sensors, and metal-organic frameworks (MOFs) due to its ability to form stable boronate esters.
• Chemical Biology & Proteomics: Acts as a versatile handle for bioconjugation and the development of activity-based probes targeting serine hydrolases and other enzymes.
• Ligand Synthesis: Serves as a starting material for creating sophisticated chiral and achiral ligands used in asymmetric catalysis.

Basic Information

Product Name	4-Fluoro-3-[(3-Fluorophenyl)(Hydroxy)Methyl]Phenylboronic Acid
CAS No.	2377587-48-7
Molecular Formula	C13H11BF2O3
Molecular Weight	264.04 g/mol
Synonyms	[4-Fluoro-3-[(3-fluorophenyl)(hydroxy)methyl]phenyl]boronic acid; 2-Fluoro-5-(3-fluorophenyl)(hydroxy)methyl]benzeneboronic acid; (4-Fluoro-3-((3-fluorophenyl)(hydroxy)methyl)phenyl)boronic acid; 4-Fluoro-3-((3-fluorophenyl)(hydroxy)methyl)benzeneboronic acid; Boronic acid, B-[4-fluoro-3-[(3-fluorophenyl)hydroxymethyl]phenyl]-; CAS 2377587-48-7
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-[(3-Fluorophenyl)(Hydroxy)Methyl]Phenylboronic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.