Description

Dbco-C-Peg1 CAS NO 2377004-09-4 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group and a carboxylic acid (C) terminus. This compound is a critical reagent in bioorthogonal click chemistry, enabling highly efficient, catalyst-free conjugation under mild physiological conditions. It is essential for researchers and manufacturers in bioconjugation, pharmaceutical development, and advanced material science who require precise and stable crosslinking for creating antibody-drug conjugates (ADCs), PEGylated therapeutics, and functionalized surfaces.

Application

• Bioconjugation and ADC Development: Site-specific conjugation of payloads (e.g., toxins, dyes, drugs) to antibodies, proteins, or peptides via the DBCO-azide cycloaddition.
• PEGylation Reagent: Introduction of a hydrophilic PEG spacer to enhance the solubility, stability, and pharmacokinetic properties of therapeutic molecules.
• Surface Functionalization: Modification of nanoparticles, biosensors, or microarray surfaces with carboxylic acid groups for further covalent attachment of biomolecules.
• Polymer and Hydrogel Synthesis: Serving as a crosslinker or functional monomer in the creation of smart biomaterials and drug delivery systems.
• Diagnostic Probe Synthesis: Construction of imaging probes and diagnostic reagents by linking targeting moieties to reporter molecules.
• Chemical Biology Tool: For labeling and studying biomolecular interactions in live cells or complex biological systems.

Basic Information

Product Name	Dbco-C-Peg1
CAS No.	2377004-09-4
Molecular Formula	C₂₄H₂₅NO₅
Molecular Weight	407.46 g/mol
Synonyms	DBCO-PEG1-COOH; DBCO-acid-PEG1; Dibenzocyclooctyne-PEG1-acid; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (2-{2-[2-(carboxymethoxy)ethoxy]ethoxy}ethyl)carbamate; DBCO-PEG1-Carboxylic Acid; Azadibenzocyclooctyne-PEG1-Acid; DBCO-C1-PEG1; DBCO-PEG1-Propionic Acid
EINECS	Contact for details

Quality Control

Our Dbco-C-Peg1 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and development applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.