Description

[S(R)]-n-[(S)-(2-Methylphenyl)[5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Methyl]-2-Methyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide ligand featuring a xantphos-derived phosphine group, designed for high-performance asymmetric catalysis. This compound matters because it enables precise stereocontrol in critical carbon-carbon and carbon-heteroatom bond-forming reactions, offering chemists a powerful tool to synthesize enantiomerically pure intermediates. Pharmaceutical R&D laboratories and fine chemical manufacturers need this advanced ligand to develop novel active pharmaceutical ingredients (APIs) and complex organic molecules with high enantiomeric excess.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric synthesis, such as cross-coupling and hydrogenation reactions.
• Critical for the stereoselective construction of chiral centers in pharmaceutical intermediates and active ingredients.
• Use in academic and industrial research for developing new catalytic methodologies.
• Production of enantiomerically pure fine chemicals for agrochemicals, flavors, and fragrances.
• As a key component in catalyst screening kits for high-throughput experimentation (HTE) in drug discovery.
• Facilitation of chiral auxiliary and organocatalyst synthesis.

Basic Information

Product Name	[S(R)]-n-[(S)-(2-Methylphenyl)[5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Methyl]-2-Methyl-2-Propanesulfinamide
CAS No.	2374225-98-4
Molecular Formula	C44H42NO2PS
Molecular Weight	679.86 g/mol
Synonyms	(SR)-N-[(S)-(2-Methylphenyl)(5-(diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)methyl]-2-methylpropane-2-sulfinamide; Chiral Xantphos Sulfinamide Ligand; (SR,S)-Xantphos Sulfinamide; Asymmetric Sulfinamide-Phosphine Hybrid Ligand; tert-Butanesulfinamide Xantphos Derivative; (SR)-2-Methyl-N-[(S)-[5-(diphenylphosphino)-9,9-dimethylxanthen-4-yl](o-tolyl)methyl]propane-2-sulfinamide; CAS 2374225-98-4
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized by advanced analytical techniques to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) are available upon request, detailing specifications such as chiral purity (enantiomeric excess), chemical purity, and residual solvent content. We adhere to cGMP principles for the production of materials intended for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at 2-8°C to maintain stability and prevent oxidation. The container should be kept in a cool, dry, and well-ventilated area, separate from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.