Description

[S(R)]-n-[(S)-[4-(1,1-Dimethylethyl)Phenyl][5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide is a sophisticated chiral sulfinamide ligand, pivotal for enabling highly selective and efficient asymmetric synthesis. Its core value lies in its ability to act as a powerful catalyst or ligand in transition metal-catalyzed reactions, providing exceptional enantioselectivity for the production of single-enantiomer intermediates. This compound is essential for pharmaceutical R&D and fine chemical manufacturers who require precise stereochemical control in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Asymmetric Catalysis: As a key chiral ligand in transition metal-catalyzed cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig amination).
• Pharmaceutical Intermediates: Synthesis of enantiomerically pure building blocks for Active Pharmaceutical Ingredients (APIs) and drug candidates.
• Agrochemical Synthesis: Production of chiral herbicides, fungicides, and pesticides with enhanced biological activity.
• Material Science: Development of chiral polymers and advanced functional materials with specific optical properties.
• Academic & Industrial R&D: A critical tool for method development in organic synthesis and catalysis research.
• Process Chemistry: Scaling up enantioselective synthetic routes for commercial manufacturing.

Basic Information

Product Name	[S(R)]-n-[(S)-[4-(1,1-Dimethylethyl)Phenyl][5-(Diphenylphosphino)-9,9-Dimethyl-9H-Xanthen-4-Yl]Methyl]-N,2-Dimethyl-2-Propanesulfinamide
CAS No.	2374225-91-7
Molecular Formula	C45H48NO2PS
Molecular Weight	698.90 g/mol
Synonyms	(SR)-N-[(S)-[4-(tert-Butyl)phenyl][5-(diphenylphosphino)-9,9-dimethyl-9H-xanthen-4-yl]methyl]-N,2-dimethylpropane-2-sulfinamide; (SR)-N-[(S)-[4-(tert-Butyl)phenyl][5-(diphenylphosphino)-9,9-dimethylxanthen-4-yl]methyl]-N,2-dimethylpropane-2-sulfinamide; Chiral Xantphos Sulfinamide Ligand; tert-Butyl-Xantphos-Sulfinamide Ligand; Asymmetric Sulfinamide Ligand; (SR,S)-DTBM-Xantphos Sulfinamide; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our production of this high-value chiral ligand adheres to strict quality protocols to ensure batch-to-batch consistency and optimal catalytic performance. Purity is rigorously verified by advanced analytical techniques including HPLC, NMR, and chiral analysis. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and chiral purity is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. This compound is easily oxidized (store under inert atmosphere) and is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.