Description

Di-tert-Butyl((2S,3S)-3-(tert-Butyl)-4-Isopropoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide is a sophisticated chiral organophosphorus compound characterized by its unique bicyclic oxaphosphole structure. This compound is of significant interest as a highly specialized ligand or catalyst precursor in advanced synthetic chemistry, particularly for asymmetric transformations. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of complex, stereochemically defined molecules.

Application

• Asymmetric Catalysis: Serving as a chiral ligand or precursor for transition metal catalysts in enantioselective synthesis.
• Pharmaceutical Intermediate Synthesis: A key building block in the research and development of novel active pharmaceutical ingredients (APIs) requiring precise stereocontrol.
• Methodology Development: Used by academic and industrial research groups to develop new catalytic protocols for C-C and C-X bond formation.
• Fine Chemical Production: Enabling the commercial-scale manufacture of optically pure agrochemicals, flavors, or fragrances.
• Material Science Research: Potential application in the development of chiral polymeric materials or advanced functional surfaces.

Basic Information

Product Name	Di-tert-Butyl((2S,3S)-3-(tert-Butyl)-4-Isopropoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide
CAS No.	2374143-32-3
Molecular Formula	C24H41O2P2
Molecular Weight	438.52 g/mol
Synonyms	(2S,3S)-Di-tert-butyl(3-tert-butyl-4-isopropoxy-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl)phosphine oxide; (2S,3S)-3-(tert-Butyl)-4-isopropoxy-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl-di-tert-butylphosphine oxide; Chiral oxaphosphole phosphine oxide ligand; DTBPO catalyst precursor; (S,S)-2374143-32-3
EINECS	Contact for details

Quality Control

Every batch of our Di-tert-Butyl((2S,3S)-3-(tert-Butyl)-4-Isopropoxy-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide is produced and analyzed under strict quality management systems. We provide comprehensive Certificates of Analysis (COA) that detail purity, enantiomeric excess, and impurity profiles, ensuring it meets the exacting standards required for research and cGMP manufacturing. Our rigorous analytical protocols, including chiral HPLC and NMR spectroscopy, guarantee batch-to-batch consistency and identity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.