Description

Di-tert-Butyl((2S,3S)-3-(tert-Butyl)-4-(2,6-Dimethoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide is a sophisticated chiral organophosphorus compound designed for advanced synthetic applications. This high-value chemical building block is critical for enabling precise stereocontrol in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel active ingredients with high enantiomeric purity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral ligand or precursor in asymmetric catalysis for the synthesis of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Employed in the development of novel, stereoselective pesticides and herbicides.
• Catalyst Development: Used in the design and synthesis of novel chiral phosphine-based catalysts for hydrogenation, cross-coupling, and other transition metal-catalyzed reactions.
• Material Science: Potential application as a monomer or additive for creating advanced polymers with specific optical or electronic properties.
• Academic & Industrial R&D: A valuable tool for methodological development in organic synthesis and stereochemistry studies.

Basic Information

Product Name	Di-tert-Butyl((2S,3S)-3-(tert-Butyl)-4-(2,6-Dimethoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide
CAS No.	2374143-28-7
Molecular Formula	C27H39O4P
Molecular Weight	458.57 g/mol
Synonyms	(2S,3S)-2-(Di-tert-butylphosphinyl)-3-(tert-butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydro-1,3-benzoxaphosphole 2-oxide; (2S,3S)-3-(tert-Butyl)-4-(2,6-dimethoxyphenyl)-2,3-dihydrobenzo[d][1,3]oxaphosphol-2-yl-di-tert-butylphosphine oxide; Chiral Dihydrobenzooxaphosphole Phosphine Oxide; Asymmetric Phosphine Oxide Ligand Precursor; CAS 2374143-28-7
EINECS	Contact for details

Quality Control

Every batch of our Di-tert-Butyl((2S,3S)-3-(tert-Butyl)-4-(2,6-Dimethoxyphenyl)-2,3-Dihydrobenzo[D][1,3]Oxaphosphol-2-Yl)Phosphine Oxide is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data, including chiral purity (enantiomeric excess) and chemical purity, verified by techniques such as HPLC, NMR, and chiral chromatography. Certificates of Analysis (COA) detailing all specifications are available for each lot to ensure traceability and compliance with your research or cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) to prevent degradation. For long-term storage, consider storing under an inert gas in a freezer (-20°C).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.