Description

Biotin-Peg8-Azide is a high-purity, heterobifunctional crosslinking reagent designed for advanced bioconjugation and click chemistry applications. This compound is critical for researchers and developers requiring precise, stable, and bioorthogonal linkages between biomolecules and various surfaces or probes. It is primarily utilized in the pharmaceutical, diagnostic, and life science research sectors for applications such as targeted drug delivery system development, biomarker labeling, and the creation of novel bioconjugates.

Application

• Bioconjugation and Click Chemistry: Serves as a key reagent for site-specific labeling of proteins, antibodies, and oligonucleotides via copper-free or copper-catalyzed azide-alkyne cycloaddition (CuAAC).
• Drug Delivery Systems: Used to functionalize liposomes, nanoparticles, and antibody-drug conjugates (ADCs) with biotin for targeted delivery and enhanced cellular uptake.
• Diagnostic Assay Development: Enables the immobilization and detection of biomolecules on streptavidin-coated surfaces in ELISA, microarray, and biosensor platforms.
• Proteomics and Biomarker Research: Facilitates the pull-down and isolation of biotinylated protein complexes for mass spectrometry analysis and interaction studies.
• Material Science and Surface Engineering: Applied to modify polymers, hydrogels, and other materials with bioactive ligands for cell culture and tissue engineering.
• Fluorescent Probe and Imaging Agent Synthesis: Acts as a building block for creating biotinylated fluorescent dyes and contrast agents for in vitro and in vivo imaging.

Basic Information

Product Name	Biotin-Peg8-Azide
CAS No.	2363756-34-5
Molecular Formula	C₃₈H₆₈N₈O₁₃S
Molecular Weight	877.06 g/mol
Synonyms	Biotin-PEG8-N3; Biotin-PEG8-Azide; Biotinylated PEG8 Azide; 5-((3aS,4S,6aR)-2-Oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)-N-(2-(2-(2-(2-(2-(2-(2-(2-azidoethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethoxy)ethyl)pentanamide; Azido-PEG8-Biotin; N3-PEG8-Biotin; Biotin-PEG8-N₃; Biotin-PEG Azide (n=8)
EINECS	Contact for details

Quality Control

Our Biotin-Peg8-Azide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and functional group analysis, to ensure compliance with research and development standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and assay is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Functional Assay (Azide)	≥ 90%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.