Description

Vh032-o-Ph-Peg1-Nh2 is a high-purity, heterobifunctional chemical linker featuring a terminal amine group and a polyethylene glycol (PEG) spacer. This compound is critical for facilitating controlled conjugation in advanced bioconjugation and pharmaceutical development, offering enhanced solubility and reduced immunogenicity. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of antibody-drug conjugates (ADCs), peptide modifications, and the development of targeted therapeutic platforms.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key building block for constructing stable, cleavable linkers between cytotoxic payloads and monoclonal antibodies.
• Peptide and Protein Modification: Used to introduce PEG chains (PEGylation) to improve pharmacokinetic properties such as half-life and stability.
• Biomolecule Immobilization: Facilitates the covalent attachment of proteins, peptides, or other amine-containing molecules to solid supports for assay and diagnostic kit development.
• Small Molecule Prodrug Synthesis: Enables the creation of targeted prodrugs by connecting active pharmaceutical ingredients to targeting ligands.
• Polymer and Material Science: Serves as a functional monomer or cross-linking agent for synthesizing smart hydrogels and biocompatible materials.
• Chemical Biology Probes: Integral for synthesizing activity-based probes and affinity labels to study enzyme function and protein interactions.

Basic Information

Product Name	Vh032-o-Ph-Peg1-Nh2
CAS No.	2361117-24-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	VH-032-O-Ph-PEG1-NH2; VH032-O-Ph-PEG1-NH2; VH032 O-Ph-PEG1-NH2; VH032 O-Phenyl-PEG1-Amine; (S)-1-((S)-2-(4-(3-((2-Aminoethoxy)methyl)phenoxy)butanamido)-3,3-dimethylbutanoyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; VHL Ligand VH032 derivative; E3 Ligase Ligand-Linker Conjugate; Heterobifunctional PROTAC Linker
EINECS	Contact for details

Quality Control

Every batch of Vh032-o-Ph-Peg1-Nh2 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes results from HPLC, NMR, and mass spectrometry. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical research and development projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic nature, the container should be sealed under an inert atmosphere (e.g., nitrogen or argon) after each use to prevent moisture absorption and degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.