Description

Protac Er Degrader-4 is a potent and selective small molecule degrader designed to target the estrogen receptor (ER) for proteasomal degradation via the PROTAC (PROteolysis TArgeting Chimera) mechanism. This compound matters as a critical research tool for investigating novel therapeutic strategies in oncology, particularly for hormone receptor-positive cancers. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on targeted protein degradation, cancer biology, and drug discovery.

Application

• Targeted Protein Degradation Research: A key chemical probe for studying PROTAC-mediated degradation of the estrogen receptor (ERα/ERβ) in cellular and biochemical assays.
• Oncology Drug Discovery: Used in preclinical research to validate the ER as a therapeutic target and to explore degradation as an alternative to traditional receptor antagonism for breast and other hormone-dependent cancers.
• Mechanism of Action Studies: Facilitates the investigation of ubiquitin-proteasome system (UPS) engagement, ternary complex formation, and kinetics of protein knockdown.
• Biomarker and Resistance Research: Employed to model and understand potential resistance mechanisms to protein degraders in cancer cell lines.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in screening campaigns for novel ER degraders or E3 ligase recruiters.
• Chemical Biology Tool: Used to elucidate the downstream signaling pathways and phenotypic consequences of acute ER loss in various biological models.

Basic Information

Product Name	Protac Er Degrader-4
CAS No.	2361114-15-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	PROTAC ER Degrader-4; ER Degrader-4; PROTAC Estrogen Receptor Degrader 4; ARV-471 analogue; Estrogen Receptor PROTAC; ER-targeting PROTAC; Proteolysis Targeting Chimera for ER; Estrogen receptor alpha degrader
EINECS	Contact for details

Quality Control

Our Protac Er Degrader-4 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.