Description

Bromoacetamido-Peg5-Dota CAS NO 2353410-19-0 is a specialized heterobifunctional linker molecule designed for the site-specific conjugation of biomolecules, such as antibodies and peptides, to chelators for radiometal labeling. This compound is critical for developing targeted radiopharmaceuticals and diagnostic imaging agents due to its precise reactivity and stable metal-chelate complex formation. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and medical diagnostics industries working on next-generation theranostics and targeted drug delivery systems.

Application

• Radiopharmaceutical Precursor: A key intermediate for synthesizing antibody-drug conjugates (ADCs) and peptides labeled with diagnostic (e.g., 68Ga, 64Cu) or therapeutic (e.g., 177Lu, 225Ac) radiometals.
• Diagnostic Imaging Probes: Construction of PET (Positron Emission Tomography) and SPECT (Single-Photon Emission Computed Tomography) imaging agents for oncology and cardiology.
• Theranostic Agent Development: Enables the creation of paired diagnostic and therapeutic agents using the same targeting vector.
• Bioconjugation & Protein Labeling: The bromoacetamido group allows for selective thiol-based conjugation to cysteine residues on proteins and peptides under mild conditions.
• Chelator Modification: Functionalization of DOTA (1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid) macrocycles with a flexible, hydrophilic PEG5 spacer to improve pharmacokinetics and reduce immunogenicity.
• Research & Development: Used in academic and industrial R&D for exploring novel targeted delivery systems and molecular imaging techniques.

Basic Information

Item	Detail
Product Name	Bromoacetamido-Peg5-Dota
CAS No.	2353410-19-0
Molecular Formula	C34H61BrN6O15
Molecular Weight	849.78 g/mol
Synonyms	Bromoacetamido-PEG5-DOTA; DOTA-PEG5-Bromoacetamide; 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid, 1-[2-[2-[2-[2-[2-(2-bromoacetamido)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl ester; Bromoacetyl-PEG5-DOTA; BnAc-PEG5-DOTA; DOTA-(PEG5)-Br; Heterobifunctional DOTA-PEG5-Bromoacetamide Linker
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg5-Dota is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D and pre-clinical applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment (desiccated) due to its hygroscopic nature. For long-term storage under inert atmosphere, it is recommended. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.