Description

Cho-Peg8-Azide is a functionalized polyethylene glycol (PEG) linker featuring a cholesterol (Cho) moiety and a terminal azide group. This bifunctional compound is engineered for the facile conjugation of biomolecules and materials via click chemistry, enabling precise control over molecular architecture. It is a critical reagent for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing advanced drug delivery systems, diagnostic probes, and novel biomaterials.

Application

• As a key building block in the synthesis of PEGylated lipid nanoparticles (LNPs) for mRNA and siRNA delivery.
• For the surface functionalization of nanoparticles and liposomes to enhance targeting capabilities and circulatory half-life.
• In the development of stimuli-responsive prodrugs and drug conjugates for controlled release applications.
• As a versatile linker for the bioconjugation of proteins, peptides, and antibodies with hydrophobic anchors.
• For creating functional hydrogels and polymeric scaffolds in tissue engineering.
• In the preparation of diagnostic imaging agents by conjugating targeting ligands with contrast agents.
• As a research tool in chemical biology for site-specific labeling of cell membranes and biomolecules.

Basic Information

Product Name	Cho-Peg8-Azide
CAS No.	2353410-13-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Cholesterol-PEG8-Azide; Chol-PEG8-N3; Azido-PEG8-cholesterol; 1-Azido-3,6,9,12,15,18,21,24-octaoxaheptacosan-27-yl 3β-cholest-5-en-3-yl carbonate; PEG8-Cholesterol Azide; Cholesterol-(ethylene glycol)8-azide; N3-PEG8-Chol
EINECS	Contact for details

Quality Control

Our Cho-Peg8-Azide is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical characterization, including NMR, HPLC, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided to guarantee the material meets the high standards required for pharmaceutical research and development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) due to its hygroscopic and potentially oxidizable nature. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. For long-term storage, desiccants are recommended.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solvent Residue (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.