Description

Azido-Peg8-Hydrazide is a heterobifunctional polyethylene glycol (PEG) linker featuring an azide group and a hydrazide terminus, connected by an 8-unit PEG spacer. This compound is essential for creating stable, site-specific bioconjugates, particularly in the development of antibody-drug conjugates (ADCs) and other advanced therapeutic modalities. Researchers and manufacturers in the fields of biopharmaceuticals, diagnostics, and materials science rely on its unique reactivity profile for precise cross-linking and functionalization of biomolecules.

Application

• Antibody-Drug Conjugate (ADC) Development: Site-specific conjugation of cytotoxic payloads to antibodies via hydrazone linkage formation.
• Biomolecule Labeling and Modification: Functionalization of proteins, peptides, and oligonucleotides through copper-free click chemistry with the azide group.
• Hydrogel and Biomaterial Synthesis: Cross-linking agent for creating PEG-based hydrogels with tailored degradation profiles for drug delivery and tissue engineering.
• Diagnostic Reagent Preparation: Conjugation of detection labels (e.g., fluorophores, enzymes) to targeting molecules for immunoassays and biosensors.
• Surface Functionalization: Modification of nanoparticles, chips, and other surfaces to introduce reactive hydrazide groups for further biomolecule immobilization.
• Polymer Chemistry: Building block for synthesizing functionalized PEG polymers and copolymers with controlled architectures.

Basic Information

Item	Information
Product Name	Azido-Peg8-Hydrazide
CAS No.	2353410-11-2
Molecular Formula	C25H50N6O11
Molecular Weight	610.7 g/mol
Synonyms	8-Azido-3,6,9,12,15,18,21,24-octaoxapentacosanoic hydrazide; Azido-PEG8-hydrazide; N3-PEG8-NHNH2; α-Azido-ω-hydrazido octaethylene glycol; PEG8 azide hydrazide; Azido-PEG8-hydrazide; Heterobifunctional PEG linker, Azide-Hydrazide, 8-unit spacer
EINECS	Contact for details

Quality Control

Our Azido-Peg8-Hydrazide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.