Description

Dbco-Peg6-Amine,Dbco-Peg6-Nh2 CAS NO 2353409-98-8 is a heterobifunctional polyethylene glycol (PEG) linker featuring a dibenzocyclooctyne (DBCO) group for strain-promoted azide-alkyne cycloaddition (SPAAC) and a primary amine group for standard amine-reactive conjugation chemistries. This compound is essential for creating stable, bioconjugate structures without the need for cytotoxic copper catalysts, making it a cornerstone for advanced bioconjugation strategies. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, antibody-drug conjugate (ADC) production, and diagnostic probe synthesis.

Application

• Bioconjugation and ADC Linker: Serves as a key building block for constructing antibody-drug conjugates (ADCs), protein-polymer conjugates, and peptide-drug conjugates via its orthogonal DBCO and amine functionalities.
• PEGylation Reagent: Used to introduce a hydrophilic, flexible PEG spacer between biomolecules (like proteins, peptides) and payloads (drugs, dyes, nanoparticles) to improve solubility, stability, and pharmacokinetics.
• Click Chemistry Reagent: Enables efficient, bioorthogonal "click" conjugation of azide-modified molecules (e.g., sugars, lipids, nucleic acids) to amine-containing surfaces or biomolecules under mild physiological conditions.
• Surface Functionalization: Facilitates the modification of amine-reactive surfaces (e.g., activated glass, carboxylated nanoparticles, N-hydroxysuccinimide ester-coated plates) with DBCO groups for subsequent capture of azide-tagged ligands.
• Cross-linking Agent: Acts as a heterobifunctional crosslinker to bridge azide-functionalized and amine-functionalized materials, polymers, or biomacromolecules.
• Diagnostic Probe Synthesis: Employed in the development of fluorescent, radioactive, or magnetic imaging probes by conjugating targeting molecules (amines) to reporter molecules (azides).
• Hydrogel and Biomaterial Fabrication: Incorporated into polymer networks to create functional, clickable hydrogels for 3D cell culture, drug delivery, and tissue engineering applications.

Basic Information

Product Name	Dbco-Peg6-Amine,Dbco-Peg6-Nh2
CAS No.	2353409-98-8
Molecular Formula	C37H56N2O9
Molecular Weight	672.86 g/mol
Synonyms	DBCO-PEG6-amine; DBCO-PEG6-NH2; DBCO-PEG6-Amine; (1R,8S,9s)-Bicyclo[6.1.0]non-4-yn-9-ylmethyl (1-{2-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]ethyl})carbamate; Dibenzocyclooctyne-PEG6-amine; DBCO-PEG6-NH2; Amine-PEG6-DBCO; Azadibenzocyclooctyne-PEG6-amine
EINECS	Contact for details

Quality Control

Our Dbco-Peg6-Amine is manufactured under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and bioconjugation applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive. Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.