Description

Gly-Gly-Gly-Peg4-Dbco is a specialized tripeptide-PEG-DBCO conjugate designed for advanced bioconjugation applications. This compound is engineered to provide a versatile linker for strain-promoted azide-alkyne cycloaddition (SPAAC) click chemistry, offering superior water solubility and reduced steric hindrance. It is essential for researchers and manufacturers in pharmaceutical development, proteomics, and diagnostic assay creation who require reliable, site-specific labeling of biomolecules.

Application

• Bioconjugation and Antibody-Drug Conjugate (ADC) Development: Serves as a cleavable or non-cleavable linker for attaching cytotoxic payloads, fluorophores, or other functional groups to antibodies and proteins.
• Proteomics and Biomarker Research: Used for labeling peptides and proteins for mass spectrometry analysis, pull-down assays, and cellular imaging studies.
• Diagnostic Reagent Formulation: Enables the stable conjugation of detection molecules (e.g., enzymes, dyes) to antibodies or oligonucleotides in ELISA, lateral flow, and other immunoassay platforms.
• Polymer and Material Science: Acts as a functional crosslinker for modifying surfaces, hydrogels, and nanoparticles to introduce bioactivity or specific targeting moieties.
• Chemical Biology Tool Development: A key reagent for creating activity-based probes, affinity tags, and other tools to study enzyme function and protein-protein interactions.
• Next-Generation Therapeutics: Facilitates the construction of complex drug delivery systems, including peptide-drug conjugates and targeted nanomedicines.

Basic Information

Product Name	Gly-Gly-Gly-Peg4-Dbco
CAS No.	2353409-80-8
Molecular Formula	C₃₃H₅₀N₆O₁₂
Molecular Weight	726.79 g/mol
Synonyms	GGG-PEG4-DBCO; Tri-Glycine-PEG4-DBCO; N-(DBCO-PEG4)-Gly-Gly-Gly; Glycyl-glycyl-glycine-PEG4-Dibenzocyclooctyne; DBCO-PEG4-triglycine; Dibenzocyclooctyne-PEG4-triglycine; Azide Reactive PEG4 Tripeptide Linker; SPAAC Reagent GGG-PEG4-DBCO
EINECS	Contact for details

Quality Control

Every batch of Gly-Gly-Gly-Peg4-Dbco is manufactured under strict quality management systems and undergoes comprehensive analytical testing. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming identity, purity, and conformity to specifications. Our quality commitment ensures the reproducibility and reliability required for critical research and cGMP manufacturing environments.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; partially soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.