Description

Bis-(m-Peg8-Amido)-Hexanoic Acid CAS NO 2353409-77-3 is a specialized bifunctional PEG-based linker molecule designed for advanced bioconjugation and pharmaceutical applications. Its core value lies in providing a hydrophilic, flexible spacer arm that enhances solubility and reduces immunogenicity in therapeutic constructs. This high-purity compound is essential for researchers and manufacturers in biopharmaceutical development, particularly for creating antibody-drug conjugates (ADCs), peptide modifications, and sophisticated drug delivery systems.

Application

• Antibody-Drug Conjugate (ADC) Linker: Serves as a critical component for attaching cytotoxic payloads to monoclonal antibodies, improving therapeutic index and stability.
• Peptide & Protein PEGylation: Used to modify peptides and proteins, enhancing their pharmacokinetic profile by increasing circulation half-life and reducing proteolytic degradation.
• Drug Delivery System Fabrication: Incorporated into nanoparticles, liposomes, and polymer-drug conjugates as a functionalized spacer to control drug release kinetics.
• Diagnostic Reagent Synthesis: Employed in the development of contrast agents and imaging probes for MRI and fluorescence imaging.
• Biomaterial Surface Functionalization: Used to create hydrophilic, non-fouling surfaces on medical devices and implants.
• Cross-linking Reagent: Acts as a homobifunctional crosslinker for coupling amines in biochemical and bioconjugation protocols.

Basic Information

Item	Details
Product Name	Bis-(m-Peg8-Amido)-Hexanoic Acid
CAS No.	2353409-77-3
Molecular Formula	C45H86N2O20
Molecular Weight	951.17 g/mol
Synonyms	1,6-Bis[2-[2-[2-[2-[2-[2-[2-(3-aminopropoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]hexane-1,6-dicarboxamide; Bis(mPEG8-amido)hexanoic acid; α,ω-Bis(3-aminopropyl-PEG8-amido)hexanoate; PEG-based heterobifunctional linker; mPEG8 spacer; Amido-PEG8-hexanoic acid derivative
EINECS	Contact for details

Quality Control

Every batch of Bis-(m-Peg8-Amido)-Hexanoic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, NMR, and Mass Spectrometry to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing purity, impurity profile, and residual solvent levels are provided with each shipment to support your GMP and R&D documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere (argon or nitrogen) to maintain stability. Allow the sealed container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.