Description

Dbco-Peg9-Dbco CAS NO 2353409-50-2 is a high-purity, heterobifunctional polyethylene glycol (PEG) linker featuring two dibenzocyclooctyne (DBCO) groups, enabling efficient, copper-free click chemistry for bioconjugation. This compound is critical for creating stable, site-specific linkages between biomolecules, nanoparticles, and surfaces without the need for cytotoxic catalysts. It is primarily needed by researchers and manufacturers in the fields of biopharmaceutical development, advanced drug delivery systems, and diagnostic assay production.

Application

• ADC (Antibody-Drug Conjugate) Linker: For the stable, site-specific conjugation of cytotoxic payloads to monoclonal antibodies.
• PEGylation Reagent: To introduce hydrophilic PEG spacers onto peptides, proteins, or nanoparticles, improving solubility and pharmacokinetics.
• Surface Functionalization: For immobilizing biomolecules onto azide-modified chips, beads, or other solid supports for biosensors and microarrays.
• Crosslinking Agent: In the synthesis of hydrogels, polymer networks, and biomaterial scaffolds for tissue engineering.
• Diagnostic Probe Conjugation: Linking fluorescent dyes, MRI contrast agents, or other reporter molecules to targeting ligands.
• Nanoparticle Modification: Functionalizing liposomes, dendrimers, or inorganic nanoparticles for targeted delivery applications.

Basic Information

Product Name	Dbco-Peg9-Dbco
CAS No.	2353409-50-2
Molecular Formula	C58H76N2O11
Molecular Weight	977.2 g/mol
Synonyms	DBCO-PEG9-DBCO; Bis-DBCO-PEG9; Dibenzocyclooctyne-PEG9-Dibenzocyclooctyne; 1,11-Bis((1R,8S,9s)-bicyclo[6.1.0]non-4-yn-9-ylmethyl)-3,6,9,12,15,18,21,24,27-nonaoxahentriacontane-1,11-dione; DBCO-(PEG)9-DBCO; Heterobifunctional PEG linker DBCO-PEG9-DBCO; Bis-DBCO PEG9 Crosslinker
EINECS	Contact for details

Quality Control

Our Dbco-Peg9-Dbco is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This compound is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid or viscous oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF, acetonitrile, chloroform

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.