Description

3-Cyclohexene-1-Propanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is a specialized Fmoc-protected amino acid derivative designed for advanced peptide synthesis. This compound is critical for introducing a unique, conformationally constrained cyclohexenyl alanine analog into peptide chains, enabling the development of novel bioactive molecules with enhanced stability and target specificity. It is an essential building block for pharmaceutical researchers and fine chemical manufacturers focused on drug discovery, particularly in creating peptide-based therapeutics, diagnostic agents, and chemical probes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a key monomer for the automated, stepwise construction of complex peptides.
• Pharmaceutical Intermediate: Serves as a crucial precursor in the research and development of new active pharmaceutical ingredients (APIs) with constrained structures.
• Peptidomimetic Design: Used to create non-natural peptide analogs where the cyclohexenyl side chain introduces rigidity to improve metabolic stability and receptor binding affinity.
• Bioconjugation and Probe Development: Facilitates the synthesis of labeled peptides for use in biochemical assays, imaging, and diagnostic applications.
• Academic and Industrial R&D: Employed in research laboratories for studying protein-protein interactions, enzyme substrates, and inhibitor design.
• Custom Peptide Service: A vital raw material for contract research and manufacturing organizations (CROs/CMOs) offering bespoke peptide production.

Basic Information

Product Name	3-Cyclohexene-1-Propanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)-
CAS No.	2351726-21-9
Molecular Formula	C24H25NO4
Molecular Weight	391.46 g/mol
Synonyms	Fmoc-(αS)-α-amino-3-cyclohexene-1-propanoic acid; Fmoc-Cha(3,4-dehydro)-OH; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(cyclohex-3-en-1-yl)propanoic acid; N-α-Fmoc-3-cyclohexenyl-L-alanine; Fmoc-δ3,4-Cha-OH; Fmoc-dehydrocyclohexylalanine; Fmoc-protected unsaturated cyclohexylalanine; Fmoc-L-3,4-dehydrocyclohexylglycine
EINECS	Contact for details

Quality Control

Our 3-Cyclohexene-1-Propanoic Acid, α-[[(9H-Fluoren-9-Ylmethoxy)Carbonyl]Amino]-, (αs)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and comprehensive identity confirmation via NMR and mass spectrometry. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research and production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.