Description

(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(3-Fluoropyridin-4-Yl)Propanoic Acid is a high-purity, non-natural amino acid derivative featuring a fluoropyridyl side chain and an Fmoc-protected α-amine. This compound matters as a critical building block for the solid-phase peptide synthesis (SPPS) of peptides designed for pharmaceutical research and development, enabling the precise incorporation of fluorinated aromatic moieties. It is essential for medicinal chemists and peptide manufacturers working on novel therapeutics, diagnostic agents, and bioactive probes where the introduction of fluorine atoms can modulate bioavailability, metabolic stability, and binding affinity.

Application

• Solid-Phase Peptide Synthesis (SPPS): Primary use as an Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: Key raw material in the research and development of peptide-based drug candidates, particularly in oncology and metabolic disease.
• Chemical Biology Probes: Incorporation into peptides used to study protein-protein interactions and enzyme activity via fluorine NMR or as a spectroscopic tag.
• Peptidomimetics Development: Serves as a scaffold for creating modified peptides with enhanced stability and pharmacological properties.
• Academic & Contract Research: Used in university laboratories and CROs for fundamental research in peptide chemistry and drug discovery projects.
• API Synthesis: Potential intermediate in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) containing fluorinated peptide sequences.

Basic Information

Product Name	(2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(3-Fluoropyridin-4-Yl)Propanoic Acid
CAS No.	2349542-06-7
Molecular Formula	C23H19FN2O4
Molecular Weight	406.41 g/mol
Synonyms	Fmoc-3-(3-fluoropyridin-4-yl)-L-alanine; Fmoc-L-3-(3-Fluoropyridin-4-yl)alanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(3-fluoropyridin-4-yl)-L-alanine; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-fluoropyridin-4-yl)propanoic acid; Fmoc-3-(3-FPy)-Ala-OH; Fmoc-3-(3-Fluoropyridin-4-yl)-Ala-OH; Fmoc-(3-F-4-Py)-Ala-OH; Nα-Fmoc-3-(3-fluoropyridin-4-yl)-L-alanine
EINECS	Contact for details

Quality Control

Our (2S)-2-({[(9H-Fluoren-9-Yl)Methoxy]Carbonyl}Amino)-3-(3-Fluoropyridin-4-Yl)Propanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) detailing identity, assay, and impurity profiles are provided and available upon request. We support compliance with REACH and other relevant global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under inert atmosphere (e.g., nitrogen) when not in use and stored in the original packaging away from direct light. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.