Description

D-Serine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-o-Propyl- is a protected derivative of the non-essential amino acid D-serine, featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group on the amine and a propyl ester on the carboxylate. This compound is a critical high-purity building block designed for advanced peptide synthesis and medicinal chemistry research, where precise stereochemistry and protecting group strategy are paramount. It is essential for pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic peptides, peptidomimetics, and other bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative, it serves as a key monomer for the controlled, sequential assembly of peptides containing D-serine residues.
• Medicinal Chemistry & Drug Discovery: Used in the research and development of peptide-based pharmaceuticals, enzyme inhibitors, and receptor ligands where the D-isomer of serine confers specific biological activity or metabolic stability.
• Biochemical Research: Employed in studies of enzyme mechanisms, substrate specificity, and the structure-activity relationships (SAR) of peptides and proteins.
• Production of Custom Peptides: A vital raw material for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) specializing in the synthesis of non-standard and complex peptides for clients.
• Protecting Group Chemistry: Acts as a model compound for studying Fmoc deprotection kinetics and optimizing synthetic methodologies in organic chemistry.

Basic Information

Product Name	D-Serine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-o-Propyl-
CAS No.	2349477-13-8
Molecular Formula	C22H23NO5
Molecular Weight	381.42 g/mol
Synonyms	Fmoc-D-Serine-OPropyl ester; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-serine propyl ester; Fmoc-D-Ser-OProp; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropanoic acid propyl ester; Propyl (R)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxypropanoate; Fmoc-D-Ser-OPr; Fmoc-D-Ser(Propyl); D-Serine Fmoc propyl ester
EINECS	Contact for details

Quality Control

Our Fmoc-protected amino acid derivatives are manufactured under strict quality systems to ensure batch-to-batch consistency and high chemical purity, suitable for demanding synthetic applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and other critical parameters. We support compliance with cGMP and ISO standards for pharmaceutical intermediates, and specifications can be aligned with customer-specific requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This product is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to prevent degradation from atmospheric moisture. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% D-isomer
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.