Description

L-Leucine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-4-Fluoro- is a specialized, high-purity amino acid derivative designed for advanced chemical synthesis. This compound is critical for researchers and manufacturers requiring precise building blocks for peptide and protein engineering. It is primarily utilized in pharmaceutical R&D, proteomics, and the development of novel bioactive molecules where the introduction of a fluorine atom and Fmoc-protected leucine moiety is essential.

Application

• Pharmaceutical Intermediate: A key building block in the solid-phase and solution-phase synthesis of fluorinated peptides and peptidomimetics for drug discovery.
• Proteomics Research: Used in the study of protein structure, function, and interactions by incorporating a stable, selectively deprotectable amino acid analog.
• Bioconjugation: Serves as a precursor for creating labeled or modified proteins and antibodies for diagnostic and therapeutic applications.
• Chemical Biology Tool: Enables the site-specific introduction of fluorine into peptides to modulate their stability, bioavailability, and binding properties.
• Advanced Material Synthesis: Potential use in creating specialized polymers or surfaces with bioactive peptide sequences.

Basic Information

Product Name	L-Leucine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-4-Fluoro-
CAS No.	2349402-75-9
Molecular Formula	C25H28FNO4
Molecular Weight	425.50 g/mol
Synonyms	Fmoc-4-fluoro-L-leucine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-fluoro-L-leucine; Fmoc-FLeu-OH; (2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-fluoro-4-methylpentanoic acid; 4-Fluoro-L-leucine, N-Fmoc derivative; Fmoc-L-4-fluoroleucine; Nα-Fmoc-4-fluoro-L-leucine; Fmoc-4-F-Leu-OH
EINECS	Contact for details

Quality Control

Our L-Leucine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-4-Fluoro- is produced under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for fine chemical and pharmaceutical intermediate manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.