Description

1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, 10-[(1S,2R)-2,3-Dihydroxy-1-(Hydroxymethyl)Propyl]- is a highly functionalized macrocyclic chelator, a key intermediate in the synthesis of advanced contrast agents for medical imaging. This compound matters for its ability to form exceptionally stable complexes with gadolinium and other lanthanide ions, which is critical for enhancing image quality and patient safety in Magnetic Resonance Imaging (MRI). Pharmaceutical R&D laboratories and fine chemical manufacturers need this high-purity building block to develop next-generation diagnostic tools.

Application

• Pharmaceutical Intermediate: Primary building block for synthesizing gadolinium-based MRI contrast agents (e.g., macrocyclic GBCAs).
• Diagnostic Imaging: Used in the development of novel, high-relaxivity contrast media for improved diagnostic accuracy.
• Research Chemical: Serves as a crucial ligand in academic and industrial research on lanthanide coordination chemistry and molecular imaging.
• Radiopharmaceuticals: Potential precursor for chelators used in Positron Emission Tomography (PET) and Single-Photon Emission Computed Tomography (SPECT) imaging when complexed with relevant radioisotopes.
• Bioconjugation: The functionalized side chain enables conjugation to targeting molecules like antibodies or peptides for targeted imaging applications.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, 10-[(1S,2R)-2,3-Dihydroxy-1-(Hydroxymethyl)Propyl]-
CAS No.	2349341-85-9
Molecular Formula	C20H35N4O9
Molecular Weight	475.52 g/mol
Synonyms	DO3A-butrol; (S)-10-[(1,2-Dihydroxy-3-methyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid; Gadobutrol precursor; Macrocyclic triacetic acid derivative; 10-[(1S,2R)-2,3-Dihydroxy-1-(hydroxymethyl)propyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid; Butrol; Intermediate for Gadovist®/Gadavist®
EINECS	Contact for details

Quality Control

Our 1,4,7,10-Tetraazacyclododecane-1,4,7-Triacetic Acid, 10-[(1S,2R)-2,3-Dihydroxy-1-(Hydroxymethyl)Propyl]- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. Certificates of Analysis (COA) with full traceability are provided, and production can be aligned with cGMP standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.