Description

n-Boc-o-Ethyl-D-Homoserine CAS NO 2348286-55-3 is a protected, non-proteinogenic amino acid derivative of significant value in advanced organic synthesis. This chiral building block is engineered to provide orthogonal protection, enabling precise and complex molecular construction. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of peptides, peptidomimetics, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for metabolic and neurological targets.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate the D-homoserine moiety with orthogonal Boc-protection for the α-amino group.
• Prodrug Development: Serves as a precursor for designing prodrugs where the ethyl ester and Boc-protected amine allow for controlled release and improved bioavailability.
• Chemical Biology Probes: Employed in the synthesis of labeled or modified amino acids for studying enzyme mechanisms and protein-protein interactions.
• Ligand and Catalyst Development: Acts as a chiral scaffold for creating novel ligands and organocatalysts used in asymmetric synthesis.
• Academic & Industrial R&D: Essential for methodological development in organic chemistry and for creating custom compound libraries for high-throughput screening.

Basic Information

Product Name	n-Boc-o-Ethyl-D-Homoserine
CAS No.	2348286-55-3
Molecular Formula	C12H23NO5
Molecular Weight	261.31 g/mol
Synonyms	D-Homoserine, N-(tert-butoxycarbonyl)-, O-ethyl ester; (2R)-2-[[(tert-Butoxy)carbonyl]amino]-4-(ethoxyoxy)butanoic acid; N-Boc-D-homoserine O-ethyl ester; tert-Butyl ((2R)-4-(ethoxyoxy)-1-hydroxy-1-oxobutan-2-yl)carbamate; Boc-D-Homoserine(OEt)-OH; (2R)-2-[(tert-Butoxycarbonyl)amino]-4-ethoxy-4-oxobutanoic acid; 2348286-55-3; Boc-D-Hse(OEt)-OH
EINECS	Contact for details

Quality Control

Every batch of n-Boc-o-Ethyl-D-Homoserine is produced and tested under strict quality management protocols to ensure high purity and consistency for research and development applications. Our products undergo rigorous quality testing, including chiral purity verification, to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee (D-isomer)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.