Description

Trpv4 Agonist-1 is a potent and selective small molecule activator of the Transient Receptor Potential Vanilloid 4 (TRPV4) ion channel. This compound is a critical research tool for investigating the physiological and pathological roles of TRPV4 in various biological systems. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on pain management, osmoregulation, and cardiovascular or pulmonary function studies. The high-purity material is essential for generating reliable and reproducible data in preclinical research.

Application

• Pharmacological Research: Used as a reference standard and tool compound for in vitro and in vivo studies of TRPV4 channel function and signaling pathways.
• Drug Discovery & Development: Serves as a lead compound or positive control in high-throughput screening (HTS) assays to identify and validate novel TRPV4-targeted therapeutics.
• Neuroscience & Pain Research: Applied in models investigating TRPV4's role in neuropathic pain, mechanical hyperalgesia, and migraine mechanisms.
• Cardiovascular & Renal Research: Utilized to study TRPV4 involvement in vascular tone regulation, endothelial function, and renal osmoregulation.
• Respiratory Disease Models: Employed in research on pulmonary edema, asthma, and chronic cough where TRPV4 activation is a key pathway.
• Cell Signaling Studies: Acts as a precise agonist to stimulate calcium influx and downstream cellular responses in transfected cell lines and primary cultures.

Basic Information

Product Name	Trpv4 Agonist-1
CAS No.	2314467-60-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	TRPV4 Agonist-1; TRPV4 agonist 1; GSK1016790A analog; 4α-PDD analog; Transient receptor potential vanilloid 4 activator; (Compound) 2314467-60-0; Research compound for TRPV4 channel
EINECS	Contact for details

Quality Control

Our Trpv4 Agonist-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and relevant analytical data. We adhere to high standards suitable for pharmaceutical research, ensuring the material meets the stringent requirements of preclinical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. For short-term use, the material may be stored at 2-8°C. The container should be allowed to reach room temperature before opening to prevent moisture condensation. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.