Description

L-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-N,β-Dimethyl-, (βr)- is a sophisticated, optically active Fmoc-protected amino acid derivative, specifically engineered for advanced peptide synthesis. This compound is critical for researchers and manufacturers requiring high-purity, stereochemically defined building blocks to ensure the structural integrity and biological activity of complex peptides. It is primarily utilized in pharmaceutical R&D, process development for novel therapeutics, and the production of specialized peptide-based active pharmaceutical ingredients (APIs).

Application

• Solid-Phase Peptide Synthesis (SPPS): Serves as a key protected amino acid monomer for the controlled assembly of peptide chains, particularly where dimethylation at the β-carbon is required.
• Pharmaceutical Research: Used in the discovery and development of peptide-based drugs, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Process Chemistry: Employed in the scale-up and GMP manufacturing of peptide APIs that incorporate modified phenylalanine residues for enhanced stability or receptor binding.
• Bioconjugation: Acts as a specialized linker or modified residue in the synthesis of peptide-drug conjugates (PDCs) and other bioconjugates.
• Chemical Biology: Utilized in the synthesis of peptide probes and tools for studying protein-protein interactions and enzyme mechanisms.
• Custom Peptide Services: A critical raw material for CROs and CDMOs offering bespoke peptide synthesis for academic and industrial clients.

Basic Information

Item	Details
Product Name	L-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-N,β-Dimethyl-, (βr)-
CAS No.	2306437-90-9
Molecular Formula	C27H27NO4
Molecular Weight	429.51 g/mol
Synonyms	Fmoc-β-Me-Phe-OH; Fmoc-β-methyl-L-phenylalanine; Fmoc-(βR)-β-methylphenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-methyl-L-phenylalanine; (2R)-3-(2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-2-carboxyethyl)benzoic acid (related); Fmoc-β-Me-Phe; Protected β-methylphenylalanine; (R)-Fmoc-β-methylphenylalanine
EINECS	Contact for details

Quality Control

Our L-Phenylalanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-N,β-Dimethyl-, (βr)- is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and cGMP applications. All batches are accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles. We adhere to relevant ICH guidelines for stability and impurity characterization to support your regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (R-isomer)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.