Description

Protac Errα Degrader-1 is a potent and selective small molecule PROTAC (PROteolysis TArgeting Chimera) designed for the targeted degradation of the estrogen-related receptor alpha (ERRα). This compound matters as a cutting-edge research tool for investigating ERRα biology and its role in metabolic diseases, oncology, and other therapeutic areas. It is primarily needed by pharmaceutical R&D teams, academic research institutions, and biotechnology companies engaged in targeted protein degradation (TPD) and drug discovery programs.

Application

• Targeted Protein Degradation Research: A critical tool for studying the PROTAC mechanism of action and validating ERRα as a therapeutic target.
• Oncology Research: Used to investigate the role of ERRα in cancer cell proliferation, metabolism, and tumor progression.
• Metabolic Disease Studies: Applied in research focused on ERRα's function in mitochondrial biogenesis, energy homeostasis, and related disorders.
• Chemical Biology & Probe Development: Serves as a starting point or benchmark compound for developing novel degraders and biological probes.
• Preclinical Drug Discovery: Utilized in in vitro and in vivo studies to assess the efficacy and pharmacokinetics of ERRα degradation.

Basic Information

Product Name	Protac Errα Degrader-1
CAS No.	2306388-84-9
Molecular Formula	C₄₀H₄₈ClN₅O₇S
Molecular Weight	778.36 g/mol
Synonyms	PROTAC ERRα Degrader-1; ERRα Degrader-1; (S,R,S)-AHPC-PEG4-C6-NH-C6-4-Hydroxytamoxifen; ARV-366; Degrader of Estrogen-Related Receptor Alpha; Estrogen Receptor-Related Alpha Degrader; ERRalpha Degrader; PROTAC ERRalpha Degrader; ERRα-targeting PROTAC
EINECS	Contact for details

Quality Control

Our Protac Errα Degrader-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and LC-MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed chromatographic and spectroscopic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.