Description

2H-Pyran-3-Carboxylic Acid, 5,5-Difluorotetrahydro-, Methyl Ester is a high-value fluorinated heterocyclic building block. This compound is critical for medicinal chemistry research and development, offering a unique structural motif for creating novel bioactive molecules. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers focused on synthesizing advanced intermediates for drug discovery programs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and metabolic disease targets.
• Medicinal Chemistry Research: Used in high-throughput screening libraries and structure-activity relationship (SAR) studies to optimize drug candidate potency and pharmacokinetic properties.
• Fluorine Chemistry: Serves as a versatile precursor for introducing the difluoromethyl ether or difluorinated tetrahydropyran moiety into complex molecules, leveraging fluorine's beneficial effects on metabolic stability and lipophilicity.
• Agrochemical Synthesis: Potential intermediate in the development of new generation herbicides and pesticides with enhanced efficacy and environmental profile.
• Material Science: Can be utilized in the research of specialty polymers and advanced materials where fluorinated components impart specific chemical resistance or surface properties.

Basic Information

Product Name	2H-Pyran-3-Carboxylic Acid, 5,5-Difluorotetrahydro-, Methyl Ester
CAS No.	2306261-85-6
Molecular Formula	C8H10F2O3
Molecular Weight	192.16 g/mol
Synonyms	Methyl 5,5-difluorotetrahydro-2H-pyran-3-carboxylate; 5,5-Difluorotetrahydro-2H-pyran-3-carboxylic acid methyl ester; Tetrahydro-5,5-difluoro-2H-pyran-3-carboxylic Acid Methyl Ester; 3-Carbomethoxy-5,5-difluorotetrahydropyran; 5,5-Difluorotetrahydropyran-3-carboxylic Acid Methyl Ester; Difluorinated Tetrahydropyran Ester; Fluorinated Pyran Building Block
EINECS	Contact for details

Quality Control

Our 2H-Pyran-3-Carboxylic Acid, 5,5-Difluorotetrahydro-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This material is easily oxidized and should be handled and stored under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.