Description

(2R)-4,4-Difluoropyrrolidine-2-Carbonitrile Hydrochloride is a high-purity chiral building block and advanced pharmaceutical intermediate. This compound is valued for its unique difluorinated pyrrolidine scaffold, which is critical for modulating the physicochemical and metabolic properties of bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and development of novel therapeutics, particularly in areas such as protease inhibition and central nervous system (CNS) targeting.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas.
• Protease Inhibitor Development: The difluoropyrrolidine motif is a privileged structure in the design of inhibitors for enzymes like dipeptidyl peptidase-4 (DPP-4) and other proteases.
• Medicinal Chemistry Research: Used as a versatile building block for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Synthesis of Fluorinated Bioisosteres: Employed to introduce fluorine atoms into target molecules, enhancing metabolic stability, membrane permeability, and binding affinity.
• Pre-clinical Candidate Synthesis: Integral to the scale-up synthesis of novel drug candidates for pre-clinical and early-phase clinical trials.
• Chemical Biology Probes: Serves as a precursor for labeled compounds or probes used to study biological pathways and enzyme functions.

Basic Information

Product Name	(2R)-4,4-Difluoropyrrolidine-2-Carbonitrile Hydrochloride
CAS No.	2306254-24-8
Molecular Formula	C5H7F2N2•HCl
Molecular Weight	164.58 (Free base) / 201.04 (HCl salt)
Synonyms	(2R)-4,4-Difluoro-2-pyrrolidinecarbonitrile hydrochloride; (R)-4,4-Difluoropyrrolidine-2-carbonitrile HCl; 4,4-Difluoro-D-prolinenitrile hydrochloride; (2R)-4,4-Difluoropyrrolidine-2-carbonitrile monohydrochloride; (R)-4,4-Difluoro-2-cyanopyrrolidine hydrochloride; 2306254-24-8; (R)-4,4-Difluoropyrrolidine-2-carbonitrile hydrochloride salt
EINECS	Contact for details

Quality Control

Our (2R)-4,4-Difluoropyrrolidine-2-Carbonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical R&D and scale-up. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); the container must be kept tightly sealed under an inert atmosphere to prevent degradation from moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.