Description

Cyclobutane, 1-Bromo-3-(Trifluoromethyl)-, trans- is a specialized fluorinated building block of significant interest in advanced organic synthesis. This compound matters for its unique structural motif, combining a reactive bromine handle with a stable trifluoromethyl group on a strained cyclobutane ring, enabling the construction of complex, value-added molecules. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for applications such as medicinal chemistry, fragment-based drug discovery, and the development of novel crop protection agents.

Application

• Key intermediate in the synthesis of novel pharmaceutical candidates, particularly for structure-activity relationship (SAR) studies.
• Building block for creating fluorinated analogs of bioactive molecules to modulate their potency, metabolic stability, and lipophilicity.
• Precursor in agrochemical research for developing new herbicides and pesticides with enhanced properties.
• Use in material science for the synthesis of fluorinated polymers or liquid crystals with specific performance characteristics.
• Versatile substrate in cross-coupling reactions (e.g., Suzuki, Negishi) facilitated by the bromine substituent.
• Fragment in medicinal chemistry for probing protein binding sites and discovering new lead compounds.

Basic Information

Product Name	Cyclobutane, 1-Bromo-3-(Trifluoromethyl)-, trans-
CAS No.	2306248-65-5
Molecular Formula	C5H6BrF3
Molecular Weight	203.00 g/mol
Synonyms	trans-1-Bromo-3-(trifluoromethyl)cyclobutane; (1r,3r)-1-Bromo-3-(trifluoromethyl)cyclobutane; 1-Bromo-3-(trifluoromethyl)cyclobutane, trans-; trans-3-(Trifluoromethyl)cyclobutyl bromide; (trans)-1-Bromo-3-(trifluoromethyl)cyclobutane; 2306248-65-5; Cyclobutane, 1-bromo-3-(trifluoromethyl)-, (1R,3R)-rel-
EINECS	Contact for details

Quality Control

Our Cyclobutane, 1-Bromo-3-(Trifluoromethyl)-, trans- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including NMR, GC, and HPLC, to ensure high chemical purity and isomeric integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your research and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept tightly sealed when not in use to prevent evaporation and potential concentration changes.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 95% (Area %)
Isomeric Purity (trans-)	≥ 98%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.