Description

4,5-Dichloro Rivaroxaban is a key pharmaceutical intermediate and a structurally modified derivative of the direct Factor Xa inhibitor, Rivaroxaban. This compound is of significant interest for research and development in novel anticoagulant therapies and for studying structure-activity relationships. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and fine chemical manufacturers focused on advanced active pharmaceutical ingredient (API) synthesis.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the research-scale synthesis of novel anticoagulant drug candidates.
• Chemical Reference Standard: Used as a high-purity analytical standard in method development and quality control for Rivaroxaban-related substances.
• Medicinal Chemistry Research: Essential for structure-activity relationship (SAR) studies to explore the impact of halogen substitution on biological activity and pharmacokinetics.
• Process Chemistry Development: Employed in the development and optimization of synthetic routes for next-generation Factor Xa inhibitors.
• Academic Research: Used in university and institutional labs for biochemical and pharmacological studies related to blood coagulation pathways.

Basic Information

Product Name	4,5-Dichloro Rivaroxaban
CAS No.	2305917-61-5
Molecular Formula	C19H16Cl2N3O5S
Molecular Weight	469.32 g/mol
Synonyms	4,5-Dichloro Rivaroxaban; Rivaroxaban 4,5-Dichloro Derivative; 5-Chloro-2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)thio)-1H-benzimidazole; 4,5-Dichloro-1-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-benzimidazol-2(3H)-one; 4,5-Dichloro Rivaroxaban Impurity; Xarelto 4,5-Dichloro Analog
EINECS	Contact for details

Quality Control

Our 4,5-Dichloro Rivaroxaban is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets high-purity standards suitable for research and development. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.