Description

3-Cyclobutoxy-4-(Difluoromethoxy)Phenylboronic Acid (Wx650128) is a high-purity boronic acid derivative, a crucial intermediate in modern synthetic organic chemistry. Its primary value lies in its role as a key building block for the Suzuki-Miyaura cross-coupling reaction, enabling the efficient construction of complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, leveraging the difluoromethoxy and cyclobutoxy motifs for enhanced biological activity and stability.
• Material Science Research: Serves as a monomer or building block for creating advanced organic materials, such as polymers and liquid crystals, with specific electronic or optical properties.
• Cross-Coupling Reactions: Primarily employed in Suzuki-Miyaura palladium-catalyzed cross-coupling to form carbon-carbon bonds, a cornerstone reaction for constructing complex molecular architectures.
• Ligand and Catalyst Development: Utilized in the preparation of novel boronic acid-based ligands and catalysts for asymmetric synthesis and other catalytic processes.
• Chemical Biology & Probe Synthesis: Acts as a versatile handle for bioconjugation and the development of molecular probes for diagnostic and biochemical research applications.

Basic Information

Product Name	3-Cyclobutoxy-4-(Difluoromethoxy)Phenylboronic Acid (Wx650128)
CAS No.	2304634-55-5
Molecular Formula	C11H13BF2O4
Molecular Weight	258.03 g/mol
Synonyms	[4-(Difluoromethoxy)-3-cyclobutoxyphenyl]boronic acid; 3-Cyclobutoxy-4-(difluoromethoxy)benzeneboronic acid; B-[4-(Difluoromethoxy)-3-cyclobutoxyphenyl]boronic acid; WX-650128; Wx650128; (4-(Difluoromethoxy)-3-cyclobutoxyphenyl)boronic Acid; 2304634-55-5
EINECS	Contact for details

Quality Control

Every batch of 3-Cyclobutoxy-4-(Difluoromethoxy)Phenylboronic Acid undergoes rigorous analytical testing to ensure it meets the high-purity standards required for sensitive cross-coupling reactions and pharmaceutical R&D. Our quality assurance protocols include validated methods such as HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to guarantee traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.