Description

(2R,2'R,3R,3'R)-3,3'-Di-tert-Butyl-4,4'-Diphenyl-2,2',3,3'-Tetrahydro-2,2'-Bibenzo[D][1,3]Oxaphosphole CAS NO 2301856-53-9 is a high-purity, chiral organophosphorus compound characterized by its unique binaphthol-derived oxaphosphole structure. This compound is of significant commercial interest as a sophisticated ligand or catalyst precursor in asymmetric synthesis, enabling the production of enantiomerically pure pharmaceuticals and fine chemicals. It is primarily utilized by R&D laboratories and production facilities in the pharmaceutical, agrochemical, and advanced materials sectors where precise stereochemical control is paramount.

Application

• As a chiral ligand in transition metal-catalyzed asymmetric reactions, including hydrogenation, cross-coupling, and C-H activation.
• As a key intermediate or catalyst precursor in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs).
• For research and development of novel asymmetric catalytic systems in academic and industrial settings.
• In the synthesis of specialty chemicals and advanced materials requiring specific stereochemistry.
• Potential use in the development of chiral stationary phases for analytical chromatography.
• As a building block for more complex phosphine-based ligand libraries.

Basic Information

Product Name	(2R,2'R,3R,3'R)-3,3'-Di-tert-Butyl-4,4'-Diphenyl-2,2',3,3'-Tetrahydro-2,2'-Bibenzo[D][1,3]Oxaphosphole
CAS No.	2301856-53-9
Molecular Formula	C38H40O2P2
Molecular Weight	590.66 g/mol
Synonyms	(R,R)-3,3'-Di-tert-butyl-4,4'-diphenyl-2,2',3,3'-tetrahydro-2,2'-bibenzo[d][1,3]oxaphosphole; (R,R)-DTB-BIBOP; Chiral Binaphthol Oxaphosphole Derivative; (2R,2'R,3R,3'R)-DTB-BIBOP; P-Chiral BINOL-Based Phosphole; (R,R)-3,3'-Di-t-butyl-4,4'-diphenyl-BIBOP; Asymmetric Diphosphine Ligand Precursor
EINECS	Contact for details

Quality Control

Our (2R,2'R,3R,3'R)-3,3'-Di-tert-Butyl-4,4'-Diphenyl-2,2',3,3'-Tetrahydro-2,2'-Bibenzo[D][1,3]Oxaphosphole is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chiral purity and assay, NMR for structural confirmation, and specific optical rotation measurement to ensure identity, strength, quality, and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Specific Optical Rotation	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.