Description

2-Fluorocyclobutanamine Hydrochloride is a high-purity, synthetically valuable organic building block. This compound is essential for medicinal chemistry research and pharmaceutical development, serving as a key chiral intermediate for constructing novel bioactive molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to introduce the unique conformational and electronic properties of the fluorinated cyclobutylamine scaffold.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of potential drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to explore the impact of fluorination on potency, metabolic stability, and bioavailability.
• Agrochemical Synthesis: Serves as a precursor for developing novel active ingredients with enhanced properties.
• Chemical Biology Probes: Utilized in the design of molecular probes to study enzyme mechanisms and biological pathways.
• Chiral Auxiliary/ Ligand Synthesis: The amine functionality and chiral center make it valuable for constructing asymmetric catalysts and ligands.
• Advanced Material Precursor: Potential use in synthesizing specialized monomers or functionalized polymers.

Basic Information

Product Name	2-Fluorocyclobutanamine Hydrochloride
CAS No.	2288709-22-6
Molecular Formula	C4H9FN • HCl
Molecular Weight	123.58 (Free base) / 160.00 (HCl salt, approx.)
Synonyms	2-Fluorocyclobutan-1-amine hydrochloride; (1R,2S)-2-Fluorocyclobutanamine hydrochloride; (1S,2R)-2-Fluorocyclobutanamine hydrochloride; 2-Fluoro-1-aminocyclobutane hydrochloride; 2-Fluorocyclobutylamine HCl; FCBA HCl; 2-F-CBA HCl; trans-2-Fluorocyclobutanamine hydrochloride
EINECS	Contact for details

Quality Control

Our 2-Fluorocyclobutanamine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and NMR/IR for structural confirmation, to ensure it meets the stringent requirements for research and development. Certificates of Analysis (COA) with full analytical data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e. (for enantiopure grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.