Description

Pomalidomide-Nh-Peg3-Azide is a high-purity, bifunctional chemical linker designed for advanced bioconjugation and PROTAC development. This compound is critical for researchers and manufacturers requiring precise, site-specific modification of biomolecules or the creation of targeted protein degraders. It is primarily utilized by pharmaceutical R&D teams and fine chemical suppliers engaged in cutting-edge therapeutic discovery, particularly in oncology and targeted drug delivery systems.

Application

• PROTAC (Proteolysis Targeting Chimera) Synthesis: Serves as a key linker component for constructing heterobifunctional molecules that recruit E3 ubiquitin ligases to target proteins for degradation.
• Antibody-Drug Conjugate (ADC) Payload Linkage: Enables the stable, click chemistry-based conjugation of cytotoxic payloads to monoclonal antibodies via its reactive azide and amine-reactive groups.
• Biomolecule Labeling and Functionalization: Used for the site-specific labeling of peptides, proteins, and oligonucleotides with fluorophores, affinity tags, or other functional moieties.
• Chemical Biology Probe Development: Facilitates the creation of activity-based probes for studying protein function and interaction networks in cellular systems.
• Polymer and Material Science: Acts as a cross-linking agent or functional initiator in the synthesis of smart polymeric materials and hydrogels for biomedical applications.
• Small Molecule Prodrug Strategies: Employed in the design of prodrugs where the PEG-azide spacer modulates solubility and pharmacokinetics.

Basic Information

Product Name	Pomalidomide-Nh-Peg3-Azide
CAS No.	2271036-46-3
Molecular Formula	C26H34N6O8
Molecular Weight	558.59 g/mol
Synonyms	Pomalidomide-PEG3-Azide; 4-((2-(2-(2-Azidoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione; Pomalidomide-PEG3-N3; Pomalidomide-amino-PEG3-azide; CC-4047-PEG3-Azide; PROTAC Linker for Pomalidomide; Azido-PEG3-Pomalidomide
EINECS	Contact for details

Quality Control

Our Pomalidomide-Nh-Peg3-Azide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high purity, suitable for sensitive research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for our clients.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.